Table 1.

Patient and Tumor Characteristics by Head and Neck Subsite

Characteristic	Patients by Subsite										P
	All Sites		Oral Cavity		Oropharynx		Larynx		Hypopharynx
	No. (N = 75,087)	%(100%)	No. (n = 36,107)	%(48.1%)	No. (n = 8,440)	%(11.2%)	No. (n = 25,624)	%(34.1%)	No. (n = 4,916)	%(6.5%)
Median follow-up time, months	69.1		68.2		55.5		79.9		43.3		< .001
Lost to follow-up	1,140	1.5	600	1.7	148	1.8	374	1.5	18	0.4	< .001
Median age, years	63.4		63.9		59.9		64.1		63.2		< .001
Sex
Male	72,300	75.6	32,725	71.0	7,525	73.2	27,310	82.3	4,740	78.1
Female	23,338	24.4	13,377	29.0	2,755	26.8	5,877	17.7	1,329	21.9	< .001
Ethnicity
White	82,304	86.1	40,915	88.7	8,567	83.3	27,993	84.3	4,829	80.0
Black	9,971	10.4	3563	7.7	1,373	13.4	4,127	12.4	908	14.9
Other	3,363	3.5	1624	3.5	340	3.3	1,067	3.2	332	5.4	< .001
N and M classification
N0 M0	39,265	47.0	20,918	51.3	1,908	20.4	15,356	54.9	1,083	19.6
N+ M0	35,434	42.4	16,093	39.5	5,972	63.9	9,940	35.5	3,429	62.1
Any N M1	8,909	10.7	3743	9.2	1,466	15.7	2,693	9.6	1,007	18.2	< .001
Treatment modality
Surgery alone	35,435	54.1	24,104	68.5	1,727	23.7	8,696	36.9	908	21.5
S + RT	23,158	35.3	8,399	23.9	3,546	48.8	9,004	38.2	2,209	52.4
RT alone	6,942	10.6	4,500	12.8	1,998	27.5	5,843	24.8	1,099	26.1	< .001
Histologic grade
Well	17,077	24.5	10,247	31.1	862	11.0	5,521	22.7	447	9.7
Moderately	33,163	47.5	15,156	46.0	3,468	44.3	12,321	50.6	2,218	48.0
Poor	17,978	25.8	6,926	21.0	3,274	41.8	5,924	24.3	1,854	40.1
Undifferentiated	1,529	2.2	600	1.8	230	2.9	592	2.4	107	2.3	< .001

NOTE. P values represent subsite comparisons on analysis of variance or χ² tests.

Abbreviations: S + RT, surgery and postoperative radiotherapy; RT, radiotherapy.