Table A1.
Crude Incidence and Location of SPM by Head and Neck Subsite
| Variable | All Sites |
Subsite |
P | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Oral Cavity |
Oropharynx |
Larynx |
Hypopharynx |
||||||||
| No. (N = 75,087) | %(100%) | No. (n = 36,107) | %(48.1%) | No. (n = 8,440) | %(11.2%) | No. (n = 25,624) | %(34.1%) | No. (n = 4,916) | %(6.5%) | ||
| Incidence of SPM | |||||||||||
| Patients with any number of SPMs | 17,441 | 23.2 | 8,294 | 23.0 | 1,674 | 19.8 | 6,594 | 25.7 | 879 | 17.9 | < .001 |
| Patients with 1 SPM | 14,720 | 19.6 | 7,004 | 19.4 | 1,230 | 14.5 | 5,723 | 22.3 | 763 | 15.5 | < .001 |
| Patients with 2 SPMs | 2,103 | 2.8 | 1,071 | 3.0 | 177 | 2.1 | 757 | 3.0 | 98 | 2.0 | < .001 |
| Patients with 3 or more SPMs | 618 | 0.8 | 219 | 0.6 | 267 | 3.1 | 114 | 0.5 | 18 | 0.4 | < .001 |
| Location of SPM | < .001 | ||||||||||
| Head and neck | 3,696 | 17.7 | 2,266 | 27.9 | 484 | 28.8 | 765 | 11.7 | 181 | 20.6 | |
| Oral cavity | 2,135 | 10.2 | 1,369 | 16.8 | 289 | 17.2 | 359 | 5.5 | 118 | 13.4 | |
| Oropharynx | 826 | 3.9 | 459 | 5.6 | 105 | 6.2 | 221 | 3.4 | 41 | 4.7 | |
| Larynx | 422 | 2.0 | 256 | 3.1 | 52 | 3.1 | 102 | 1.6 | 12 | 1.4 | |
| Hypopharynx | 313 | 1.5 | 182 | 2.2 | 38 | 2.2 | 83 | 1.3 | 10 | 1.1 | |
| Lung and bronchus | 5,394 | 25.8 | 2,049 | 25.2 | 529 | 31.5 | 2,487 | 38.0 | 329 | 37.4 | |
| Esophagus | 861 | 4.1 | 433 | 5.3 | 103 | 6.2 | 220 | 3.4 | 105 | 11.9 | |
| All non-HNLE sites | 7,281 | 34.8 | 3,386 | 41.6 | 566 | 33.7 | 3,065 | 46.9 | 264 | 30.0 | |
NOTE. P values represent subsite comparisons on analysis of variance or χ2 tests.
Abbreviations: SPM, second primary malignancy; HNLE, head and neck, lung, and esophagus.