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. 2011 Mar 14;6(3):e14757. doi: 10.1371/journal.pone.0014757

Table 2. Commonly dysregulated genes in regions of relative copy number alterations in PPP tolerant Line2-T500 and Line3-T200 cells (data by Nexus analyses).

Gene symbol Location Locus
Gene name Chr. start-end (Mb) Link ID
Upregulated genes within regions of relative copy number gain
FXR1 fragile X mental retardation, autosomal homolog 1 3 182.1–182.3 8087
CUGBP2 CUG triplet repeat, RNA binding protein 2 10 11.1–11.5 10659
ACP2 acid phosphatase 2, lysosomal 11 42.2–42.3 53
CUGBP1 CUG triplet repeat, RNA binding protein 1 11 47.4–47.6 10658
FNBP4 formin binding protein 4 11 47.7–47.8 23360
PATL1 protein associated with topoisomerase II homolog 1 11 59.1–59.2 219988
NAT11 N-acetyltransferase 11 (GCN5-related, putative) 11 63.4–63.5 79829
GPR137 G protein-coupled receptor 137 11 63.8–63.9 56834
ATG2A ATG2 autophagy related 2 homolog A 11 64.4–64.5 23130
PPP2R5B protein phosphatase 2, regulatory subunit B', 11 64.4–64.5 5526
EHBP1L1 EH domain binding protein 1-like 1 11 65.1–65.2 254102
ADRBK1 adrenergic, beta, receptor kinase 1 11 66.7–66.9 156
RAD9A RAD9 homolog A 11 66.9–67.0 5883
CABP4 calcium binding protein 4 11 66.9–67.0 57010
ACY3 aspartoacylase 3 11 67.1–67.2 91703
CTTN Cortactin 11 66.9–67.0 2017
C11orf30 chromosome 11 open reading frame 30 11 75.8–76.0 56946
RAB30 RAB30, member RAS oncogene family 11 82.3–82.5 27314
TMEM126B transmembrane protein 126B 11 85.0–85.1 55863
PICALM phosphatidylinositol binding clathrin assembly protein 11 85.3–85.5 8301
NEK3 NIMA (never in mitosis gene a)-related kinase 3 13 51.6–51.7 4752
UBL3 ubiquitin-like 3 13 29.2–29.4 5412
TDRD3 tudor domain containing 3 13 59.8–60.1 81550
Downregulated genes within regions of relative copy number decrease
RAD52 RAD52 homolog 12 0.8–1.0 5893
FBXL14 F-box and leucine-rich repeat protein 14 12 1.5–1.6 144699
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 12 1.7–1.9 93589
ITFG2 integrin alpha FG-GAP repeat containing 2 12 2.7–2.9 55846
LRRC23 leucine rich repeat containing 23 12 6.8–6.9 10233
H3F3B H3 histone, family 3B 17 71.2–71.3 3021
SOCS3 suppressor of cytokine signaling 3 17 73.8–73.9 9021
RNF213 ring finger protein 213 17 75.9–76.0 57674