Table 4. Validation of identified genes by siRNA treatment.

Downregulated genes
		Negative	ALDH1A3		ANXA1		TLR4		SPIN3		SOCS3		RAB5A
Line2	Mean	0.555	0.718	↑*	0.746	↑*	0.628	↑*	0.582	NS	0.549	NS	0.661	↑
	SEM	0.0015	0.0163		0.0273		0.0080		0.0295		0.0033		0.0449
Line3	Mean	0.494	0.529	↑*	0.601	↑*	0.596	↑	0.568	↑*	0.508	NS	0.659	↑*
	SEM	0.0047	0.0111		0.0284		0.0498		0.0087		0.0060		0.0316
BE	Mean	0.662	0.732	↑*	0.861	↑*	0.701	NS	0.876	↑*	0.698	↑*	0.799	↑*
	SEM	0.0073	0.0047		0.0143		0.0383		0.0208		0.0058		0.0407
MCF7	Mean	0.600	0.768	↑*	0.745	↑*	0.696	↑*	0.674	NS	0.712	↑*	0.673	↑
	SEM	0.0288	0.0209		0.0192		0.0195		0.0297		0.0105		0.0232

The PPP sensitivity ratio was calculated as fluorescence from wells treated with PPP to those treated without PPP.

Statistical significance was calculated using the T test compared to the wells treated with negative control siRNA.

↓  =  Trend in decreased tolerance to PPP, p<0.1; ↓*  =  Significant decreased tolerance to PPP, p<0.05.

↑  =  Trend in increased tolerance to PPP, p<0.1; ↑*  =  Significant increased tolerance to PPP, p<0.05.

NS  =  No statistically significant change.