Fig. 3. Megakaryocyte morphology and in vitro platelet formation potential in mafG^+/–::mafK^+/– and mafG^–/–::mafK^+/– mice. Megakaryocytes were isolated from the bone marrow of mafG^–/–::mafK^+/– mice (A and B) or mafG^+/–::mafK^+/– mice (C and D). The morphology of both was examined by Giemsa staining (A and C). After plating into culture dishes, control megakaryocytes formed proplatelet projections after 24 h in culture (D), while megakaryocytes recovered from mafG^–/–::mafK^+/– mutants showed no propensity for megakaryocyte fragmentation or proplatelet formation (B).