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. 2011 Feb 27;9:7. doi: 10.1186/1477-3155-9-7

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Copyright ©2011 Yu et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Synthesis of PEG-PPS-based polymer-biomolecule conjugates. The PPS block is formed by anionic ring-opening polymerization of an episulfide monomer, and endcapped with methyl acrylate. Conversion of the terminal methyl ester group to a carboxylic acid is accomplished under highly basic conditions to enable subsequent coupling of a PEG block and then a biofunctional ligand (e.g., peptides, amine-functionalized ssDNA) in modular fashion, yielding PEG-PPS-based polymer-biomolecule conjugates.