Table 4.

GSEA for Early Developmental Biology GO sets.

Comparison	Keyword	Gene Set	Gene Set Description	Size	p-value Exp. 2	Significant Genes	p-value Exp. 1
Control vs ALC-NTO/ALC-NTC (see legends)	Growth, Growth Regulation*	GO:0016049 GO:0040007	^Cell growth ^Growth	47 75	0.002 0.005	(Ctgf, Igfbp2, Emp1, Osm, Cyr61, Gap43, Crim1, Tgfb3, Igfbp7, Nov, Emp3), Gpc3, Csf1, Socs2, Bmp6, Bmp4, Inhbb, Lepre1, Wrn, Wig1, Cish	0.010 0.010
		GO:0001558 GO:0040008	Regulation of cell growth Regulation of growth	39 56	0.002 0.016	(Ctgf, Igfbp2, Osm, Cyr61, Gap43, Crim1, Igfbp7, Nov), Gpc3, Csf1, Socs2,	0.006 0.017
		GO:0005520	Insulin-like growth factor binding	14	0.000	Ctgf, Igfbp2, Cyr61, Crim1, Igfbp7, Nov	0.012
	Heart*	GO:0001525	Angiogenesis	53	0.022	Ctgf, Anxa2, Cyr61, Thbs1, Vegfa, Tie1, Elk3, Flt1, Crhr2, Vegfc, Kdr, Bmp4, Adra2b, Tnfrsf12a	0.022
	Eye#	GO:0001654	Eye Development	26	0.040	Mab21l1, Neurod1, Neurod4, Ntrk2, Fkbp8, Bmpr1b, Crb1, Stat3, Tspan5, Pax6, Bmp4, Map3k1	0.004
	Epigenetic factor~,^	GO:0006334	Nucleosome modeling	30	0.021	Hist3h2b, a; Hist1h3f; Hist1h1c; Hist1h2b, c; Hist1h3a; H1f0; Smarca2; Nap1l3	0.033
ALC-NTO vs ALC-NTC	Growth, Growth retardation	GO:0007173	Epidermal growth factor receptor (EGFR) signaling pathway	5	0.019	Pde6g, Egfr, Hbegf (Enriched in ALC-NTC)	0.023

^= Gene set reduced in ALC-NTO as compared with Control.

*= Gene sets reduced in ALC (all alcohol group) and ALC-NTC as compared with Control.

~= Gene set reduced in ALC as compared with Control

#= Gene set reduced in ALC-NTC as compared with Control.

( ) = genes in Cell growth related GO set, which is included in Growth GO set; or genes in Regulation of Cell growth related GO set, which is included in Regulation of Growth GO set.