Table 3.
Differentially-regulated genes of our interest in spleens of mice with JEV Infection
| Genbank Accession | Gene symbol | Gene description | Fold change | p-Value |
|---|---|---|---|---|
| Up-regulated | ||||
| NM_177261 | Kndc1 | kinase non-catalytic C-lobe domain (KIND) containing 1 | 21.440 | 0.0252 |
| NM_019494 | Cxcl11 | chemokine (C-X-C motif) ligand 11 | 19.752 | 0.0084 |
| NM_013542 | Gzmb | granzyme B | 6.202 | 0.0286 |
| NM_031167 | Il1rn | interleukin 1 receptor antagonist (Il1rn), transcript variant 1 | 6.060 | 0.0015 |
| AK157531 | LOC629091 | activated spleen cDNA, RIKEN full-length enriched library, clone:F830221E13 | 5.500 | 0.0154 |
| NM_001033228 | Itga1 | integrin alpha 1 | 5.482 | 0.0308 |
| NM_013584 | Lifr | leukemia inhibitory factor receptor | 5.319 | 0.0109 |
| NM_177923 | H2-M10.2 | histocompatibility 2, M region locus 10.2 | 5.276 | 0.0009 |
| NM_008198 | Cfb | complement factor B | 5.188 | 0.0019 |
| NM_001005858 | LOC667370 | similar to interferon-induced protein with tetratricopeptide repeats 3 | 4.949 | 0.0459 |
| NM_145153 | Oas1f | 2'-5' oligoadenylate synthetase 1F | 4.619 | 0.0013 |
| NM_011331 | Ccl12 | chemokine (C-C motif) ligand 12 | 4.539 | 0.0308 |
| NM_027893 | Pvrl4 | poliovirus receptor-related 4 | 4.429 | 0.0352 |
| NM_010741 | Ly6c | lymphocyte antigen 6 complex, locus C | 4.287 | 0.0042 |
| NM_010370 | Gzma | granzyme A | 4.236 | 0.0010 |
| NM_009152 | Sema3a | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 4.132 | 0.0358 |
| AF229257 | Usp29 | ubiquitin-specific processing protease 29 | 4.033 | 0.0093 |
| NM_133871 | Ifi44 | interferon-induced protein 44 | 3.843 | 0.0053 |
| NM_009912 | Ccr1 | chemokine (C-C motif) receptor 1 | 3.734 | 0.0013 |
| BC025535 | Fcgr1 | Fc receptor, IgG, high affinity I | 3.668 | 0.0096 |
| NM_145226 | Oas3 | 2'-5' oligoadenylate synthetase 3 | 3.531 | 0.0017 |
| NM_008331 | Ifit1 | interferon-induced protein with tetratricopeptide repeats 1 | 3.433 | 0.0460 |
| NM_021274 | Cxcl10 | chemokine (C-X-C motif) ligand 10 | 3.418 | 0.0307 |
| NM_016850 | Irf7 | interferon regulatory factor 7 | 3.378 | 0.0083 |
| NM_008530 | Ly6f | lymphocyte antigen 6 complex, locus F | 3.313 | 0.0027 |
| NM_011940 | Ifi202b | interferon activated gene 202B | 3.296 | 0.0266 |
| NM_145211 | Oas1a | 2'-5' oligoadenylate synthetase 1A | 3.283 | 0.0082 |
| NM_145227 | Oas2 | 2'-5' oligoadenylate synthetase 2 | 3.178 | 0.0083 |
| NM_144559 | Fcgr4 | Fc receptor, IgG, low affinity IV | 3.069 | 0.0067 |
| NM_027835 | Ifih1 | interferon induced with helicase C domain 1 | 2.940 | 0.0258 |
| NM_008462 | Klra2 | killer cell lectin-like receptor, subfamily A, member 2 | 2.906 | 0.0001 |
| NM_021792 | Iigp1 | interferon inducible GTPase 1 | 2.535 | 0.0232 |
| L38281 | Irg1 | immune-responsive gene 1 | 2.496 | 0.0329 |
| NM_008329 | Ifi204 | interferon activated gene 204 | 2.422 | 0.0290 |
| NM_025378 | Ifitm3 | interferon induced transmembrane protein 3 | 2.401 | 0.0002 |
| NM_021378 | Klrc3 | killer cell lectin-like receptor subfamily C, member 3 | 2.396 | 0.0063 |
| NM_011909 | Usp18 | ubiquitin specific peptidase 18 | 2.333 | 0.0473 |
| NM_011333 | Ccl2 | chemokine (C-C motif) ligand 2 | 2.314 | 0.0356 |
| NM_028968 | Ifitm7 | interferon induced transmembrane protein 7 | 2.246 | 0.0014 |
| NM_008337 | Ifng | interferon gamma | 2.229 | 0.0054 |
| NM_011338 | Ccl9 | chemokine (C-C motif) ligand 9 | 2.155 | 0.0065 |
| NM_010653 | Klrc2 | killer cell lectin-like receptor subfamily C, member 2 | 2.131 | 0.0076 |
| NM_009909 | Il8rb | interleukin 8 receptor, beta | 2.077 | 0.0036 |
| NM_010555 | Il1r2 | interleukin 1 receptor, type II | 2.069 | 0.0248 |
| NM_010652 | Klrc1 | killer cell lectin-like receptor subfamily C, member 1 | 2.025 | 0.0125 |
| NM_011073 | Prf1 | perforin 1 (pore forming protein) | 1.820 | 0.0326 |
| NM_010722 | Lmnb2 | lamin B2 | 1.381 | 0.1976 |
| Down-regulated | ||||
| NM_025989 | Gp2 | glycoprotein 2 (zymogen granule membrane) | 0.048 | 0.0005 |
| NM_053094 | Cd163 | CD163 antigen | 0.060 | 0.0171 |
| NM_177261 | Kndc1 | kinase non-catalytic C-lobe domain (KIND) containing 1 | 0.085 | 0.0070 |
| NM_144943 | Cd207 | CD 207 antigen | 0.159 | 0.0441 |
| NM_010378 | H2-Aa | histocompatibility 2, class II antigen A, alpha | 0.184 | 0.0055 |
| NM_028135 | Tmem163 | transmembrane protein 163 | 0.211 | 0.0196 |
| NM_007720 | Ccr8 | chemokine (C-C motif) receptor 8 | 0.242 | 0.0150 |
| NM_016851 | Irf6 | interferon regulatory factor 6 | 0.261 | 0.0037 |
| NM_013509 | Eno2 | enolase 2, gamma neuronal (Eno2) | 0.276 | 0.0234 |
| NM_011780 | Adam23 | a disintegrin and metallopeptidase domain 23 (Adam23) | 0.281 | 0.0009 |
| U96752 | H2-Q1 | major histocompability complex Q1b | 0.282 | 0.0247 |
| NM_008341 | Igfbp1 | insulin-like growth factor binding protein 1 | 0.289 | 0.0144 |
| NM_010565 | Inhbc | inhibin beta-C (Inhbc) | 0.304 | 0.0307 |
| AK089361 | AK089361 | B6-derived CD11 +ve dendritic cells cDNA | 0.307 | 0.0417 |
| NM_013517 | Fcer2a | Fc receptor, IgE, low affinity II, alpha polypeptide | 0.315 | 0.0318 |
| NM_016808 | Usp2 | ubiquitin specific peptidase 2 (Usp2), transcript variant 1 | 0.319 | 0.0266 |
| AK041838 | Il7r | interleukin 7 receptor | 0.319 | 0.0256 |
| NM_001033126 | Cd27 | CD antigen 27 (Cd27), transcript variant 1 | 0.326 | 0.0158 |
| NM_009142 | Cx3cl1 | chemokine (C-X3-C motif) ligand 1 | 0.343 | 0.0227 |
| NM_010215 | Il4i1 | interleukin 4 induced 1 | 0.387 | 0.0129 |
| NM_207105 | H2-Ab1 | histocompatibility 2, class II antigen A, beta 1 | 0.520 | 0.0255 |
| NM_033217 | Ngfr | nerve growth factor receptor (TNFR superfamily, member 16) | 0.440 | 0.0110 |
| AK041345 | Xlr4a | X-linked lymphocyte-regulated 4A | 0.460 | 0.0074 |
| NM_033042 | Tnfrsf25 | tumor necrosis factor receptor superfamily, member 25 | 0.465 | 0.0366 |
| NM_198297 | Trat1 | T cell receptor associated transmembrane adaptor 1 | 0.476 | 0.0334 |
| NM_011161 | Mapk11 | mitogen-activated protein kinase 11 | 0.478 | 0.0128 |
| NM_007549 | Blk | B lymphoid kinase | 0.483 | 0.0103 |
| NM_010818 | Cd200 | Cd200 antigen | 0.494 | 0.0156 |