Table 5.
Proportion of patients showing satisfactory improvement of individual symptoms
| Week 4 | Week 8 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Omeprazole Improvement, % |
Other drugs Improvement, % |
Difference (95% CI) | p-value* | Omeprazole Improvement, % |
Other drugs Improvement, % |
Difference (95% CI) | p-value* | |||
| Stomach pain | 71.7 (1107/1544) | 64.1 (257/401) | 7.6 | (2.4, 12.8) | 0.003 | 83.7 (1018/1216) | 74.9 (230/307) | 8.8 | (3.5, 14.1) | < 0.001 |
| Heavy feeling in the stomach | 61.7 (1467/2379) | 45.9 (299/652) | 15.8 | (11.5, 20.1) | < 0.001 | 77.0 (1465/1903) | 64.0 (330/516) | 13.0 | (8.5, 17.6) | < 0.001 |
| Nausea | 72.1 (1079/1497) | 62.0 (246/397) | 10.1 | (4.8, 15.4) | < 0.001 | 85.1 (1013/1191) | 74.2 (227/306) | 10.9 | (5.6, 16.2) | < 0.001 |
| Irritating sensation in the throat | 68.4 (726/1061) | 69.1 (170/246) | -0.7 | (-7.1, 5.7) | 0.836 | 77.8 (657/844) | 71.4 (135/189) | 6.4 | (-0.6, 13.4) | 0.059 |
| Acid or bitter taste due to refluxed fluid | 70.7 (1502/2124) | 58.4 (320/548) | 12.3 | (7.8, 16.9) | < 0.001 | 85.4 (1492/1747) | 72.9 (315/432) | 12.5 | (8.0, 17.0) | < 0.001 |
| Stomach bloating sensation | 66.4 (878/1322) | 56.7 (202/356) | 9.7 | (3.9, 15.4) | < 0.001 | 81.5 (882/1082) | 74.0 (211/285) | 7.5 | (1.9, 13.1) | 0.005 |
| Choking sensation in the throat | 66.8 (641/959) | 64.7 (152/235) | 2.2 | (-4.6, 9.0) | 0.530 | 78.6 (611/777) | 68.9 (126/183) | 9.8 | (2.5, 17.1) | 0.005 |
| Burning sensation from stomach or lower chest toward the neck | 78.9 (1097/1391) | 69.2 (225/325) | 9.6 | (4.2, 15.1) | < 0.001 | 88.4 (989/1119) | 77.0 (207/269) | 11.4 | (6.1, 16.8) | < 0.001 |
| Belching | 60.7 (940/1548) | 49.3 (197/400) | 11.5 | (6.0, 16.9) | < 0.001 | 74.3 (947/1275) | 64.4 (206/320) | 9.9 | (4.1, 15.7) | < 0.001 |
| Loss of appetite | 75.4 (771/1022) | 66.2 (178/269) | 9.3 | (3.0, 15.5) | 0.002 | 85.3 (721/845) | 75.1 (154/205) | 10.2 | (3.8, 16.6) | < 0.001 |
| Early satiety | 68.8 (698/1015) | 62.0 (178/287) | 6.7 | (0.5, 13.0) | 0.031 | 80.5 (656/815) | 72.0 (167/232) | 8.5 | (2.1, 14.9) | 0.005 |
| Coughing | 62.9 (450/715) | 58.9 (103/175) | 4.1 | (-4.0, 12.2) | 0.319 | 74.6 (432/579) | 68.7 (101/147) | 5.9 | (-2.4, 14.2) | 0.148 |
* χ2 test. CI = confidence interval.