Table 3.
DHA noncompartmental pharmacokinetic data in pregnant, postpartum, and non-pregnant women with Plasmodium falciparum infection.
| Pregnant cases | P-value | |||||
|---|---|---|---|---|---|---|
| Parameters | Ante-partum | Post-partum (3 months) |
Non-pregnant controls | Ante vs. Post* | Ante vs. Non-pregnant controls† | Post vs. Non-pregnant controls† |
| Cmax (ng/mL) | 904.6 [363.9 - 2541.9] |
979.5 [414.5 - 2246.3] |
1284.7 [539.8 - 3259.4] |
0.89 | 0.24 | 0.090 |
| Tmax (h) | 1.50 [0.25 - 6.00] |
1.50 [0.50 - 4.00] |
1.52 [0.50 - 4.03] |
0.95 | 0.57 | 0.34 |
| AUCall (ng*h/mL) | 1730.5 [1034.7 - 4085.5] |
2122.2 [1308.9 - 4054.9] |
2787.0 [1244.8 - 6363.5] |
0.0080 | 0.0018 | 0.021 |
| AUCfree (ng*h/mL) | 398.5 [138.7 - 663.9] |
373.0 [186.5 - 708.3] |
504.6 [197.9 - 1301.3] |
0.80 | 0.057 | 0.043 |
| CL/F (L/h) | 85.5 [36.2 - 142.9] |
69.7 [36.5 - 113.0] |
53.1 [23.2 - 118.8] |
0.0035 | 0.0018 | 0.021 |
| CL/F (L/kg/h) | 1.39 [0.75 - 2.46] |
1.26 [0.63 - 2.32] |
1.07 [0.53 - 1.89] |
0.033 | 0.0025 | 0.011 |
| T½ (h) | 1.28 [0.83 - 2.71] |
1.63 [0.92 - 2.18] |
1.41 [0.86 - 6.55] |
0.021 | 0.28 | 0.27 |
| Vd/F (L) | 157.4 [59.9 - 335.9] |
158.3 [66.0 - 332.7] |
128.2 [38.5 - 400.1] |
0.82 | 0.098 | 0.071 |
| Vd/F (L/kg) | 2.84 [1.25 - 5.33] |
3.00 [1.55 - 5.37] |
2.45 [0.78 - 6.56] |
0.54 | 0.17 | 0.083 |
| FF | 0.21 [0.13 - 0.31] |
0.19 [0.11 - 0.27] |
0.18 [0.09 - 0.39] |
0.014 | 0.031 | 0.82 |
Medians [range] and nonparametric comparison of groups
* Wilcoxon signed rank test.
† Wilcoxon rank sum test.