Table 4.
DHA noncompartmental pharmacokinetic data in pregnant, postpartum, and non-pregnant women with Plasmodium falciparum infection.
| Antepartum vs. Postpartum* | Antepartum vs. Non-pregnant controls† | Postpartum vs. Non-pregnant controls† | ||||
|---|---|---|---|---|---|---|
| Parameters | Estimate (90% CI) |
P-value | Estimate (90% CI) |
P-value | Estimate (90% CI) |
P-value |
| Cmax (ng/mL) | 1.06 (0.87, 1.30) | 0.62 | 0.81 (0.63, 1.03) | 0.15 | 0.77 (0.61, 0.98) | 0.070 |
| Tmax (h) | 0.99 (0.74, 1.33) | 0.95 | 0.90 (0.66, 1.23) | 0.58 | 0.89 (0.67, 1.17) | 0.47 |
| AUCall (ng*h/mL) | 0.87 (0.77, 0.98) | 0.064 | 0.68 (0.57, 0.81) | 0.0004 | 0.78 (0.66, 0.92) | 0.014 |
| AUCfree (ng*h/mL) | 0.99 (0.85, 1.15) | 0.92 | 0.78 (0.63, 0.95) | 0.039 | 0.78 (0.65, 0.95) | 0.038 |
| CL/F (L/h) | 1.21 (1.09, 1.33)‡ | 0.0075 | 1.48 (1.24, 1.76) | 0.0004 | 1.29 (1.09, 1.52) | 0.014 |
| CL/F (L/kg/h) | 1.16 (1.03, 1.29)‡ | 0.040 | 1.36 (1.18, 1.57) | 0.0008 | 1.24 (1.07, 1.44) | 0.016 |
| T½ (h) | 0.84 (0.75, 0.96) | 0.028 | 0.86 (0.72, 1.02) | 0.15 | 1.03 (0.86, 1.22) | 0.80 |
| Vd/F (L) | 0.97 (0.83, 1.14) | 0.74 | 1.26 (1.00, 1.60) | 0.097 | 1.32 (1.04, 1.67) | 0.056 |
| Vd/F (L/kg) | 0.95 (0.81, 1.12) | 0.61 | 1.18 (0.96, 1.44) | 0.19 | 1.26 (1.02, 1.56) | 0.073 |
| FF | 1.14 (1.05, 1.24) | 0.013 | 1.15 (1.02, 1.28) | 0.051 | 1.01 (0.89, 1.14) | 0.92 |
Relative estimates (90% CIs) and parametric tests for group comparisons
* Geometric mean antepartum:postpartum ratio and 90% CI; 1-sample t-test on logged ratios.
† Ratio of geometric means and 90% CI; 2-sample t-test on logged data
‡ Mean antepartum:postpartum ratio and 90% CI; 1-sample t-test on ratio