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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Mol Immunol. 2011 Feb 12;48(8):1009–1018. doi: 10.1016/j.molimm.2011.01.006

Figure 1. Algorithm for SIR score computation.

Figure 1

Each human protein is divided into all ninemers and the appropriate flanking regions (a). For each ninemer a cleavage score is computed (b). For all ninemers with a positive cleavage score, a TAP binding was computed and supra-threshold peptides were chosen (c). The MHC binding score of all TAP binding and cleaved ninemers was computed (d). Ninemers passing all these selection stages are defined as epitopes. (e) The number of epitopes per protein per HLA allele was then calculated.