Fig. 1.

3′ RACE analysis of Nox3^het transcripts. 3′ RACE analysis of Nox3^het/Nox3^het inner-ear total RNA reveals the aberrant splicing products shown here that terminate in a sequence showing similarity to the sequences of mouse endogenous retroviruses. Alternating black lines with numbers, genome coordinates on Chromosome 17 (build 37); top schematic, 3′ RACE products from wild-type RNA; remaining schematics, 3′ RACE products from mutant RNA that splice into an exon derived from the endogenous retroviral sequence (ERV), may include a cryptic exon (C) or may skip exons 11 and 12. The size difference observed between the second and third mutants' 3′ RACE products is due to a difference in the size of included ERV sequence