Fig. 4.

Substrate specificity of eukaryotic structure-selective junction endonucleases. Mapped incision sites for Rad1 (green triangles), Mus81 (yellow triangles), Yen1/GEN1 (purple triangles), and Slx1–Slx4 (orange triangles) are indicated. The incision sites for Slx4 on replication forks have not been mapped and are therefore not represented. D-Loop, displacement loop; nHJ, nicked Holliday junction; RF, replication fork; NER, nucleotide excision repair; SSA, single-strand annealing; Model RF, model replication fork; Exo, exonuclease activity