Table 1.

Principal ADAMs proteinases involved in skin diseases.

ADAM	substrate	Pathology association
ADAM9	HB-EGF, EGF, Collagen XVII	Cancer, Wound healing
ADAM10	E-cadherin, N-cadherin, CD44, EGF, HB-EGF, L1-CAM, CXCL16 Collagen XVII	Cancer, Wound healing, Psoriasis, Eczema
ADAM12	EGF, HB-EGF	Cancer, Wound healing, Psoriasis
ADAM17	TNF-α, TNFR, TGF-α, HB-EGF, AR, Collagen XVII, KIT, SCF	Cancer, Migration, Psoriasis, Melanogenesis, SSc
ADAM33		Psoriasis