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(A) pTyr peptide (ball and stick) bound to the SH2 domain of Lck. The key NH amide moiety linking the pTyr (red bar) and Glu residues is highlighted (white arrow) and shown within hydrogen-bonding distance of the His-180 carbonyl (space filling).9b (B) PKA substrate peptide (ball and stick) complexed with an ATP transition state mimic (ADP/AlF3; yellow space filling). The phosphoryl acceptor Ser (red arrow) and the key amide NH (white arrow) are highlighted.14
