Table 2.
Geometric mean differences in plasma concentrations according to corresponding SNPs stratified by ethnicity
| Gene | SNP ID | White | Black | Hispanics | Asian/Pacific Islanders | All | P-value for ethnic interactionb |
|---|---|---|---|---|---|---|---|
| Difference in mean logarithms (SE)a | Difference in mean logarithms (SE) | Difference in mean logarithms (SE) | Difference in mean logarithms (SE) | Difference in mean logarithms (SE) | |||
| TNF-α | (n=1,592) | (n=912) | (n=328) | (n=209) | (n=3,041) | ||
| rs2239705 | −0.02 (0.01) | −0.03 (0.02) | 0.002 (0.03) | 0.04 (0.04) | 0.003 (0.01) | 0.03 | |
| rs2230365 | −0.04 (0.01)c | −0.04 (0.03) | −0.02 (0.03) | −0.06 (0.03) | −0.02 (0.01) | 0.86 | |
| rs2009658 | −0.03 (0.01) | −0.04 (0.02) | 0.01 (0.03) | −0.05 (0.04) | −0.02 (0.01) | 0.73 | |
| rs2239704 | −0.02 (0.01) | −0.002 (0.02) | −0.005 (0.02) | −0.01 (0.03) | 0.001 (0.01) | 0.25 | |
| rs909253 | 0.04 (0.01)d | 0.01 (0.02) | 0.02 (0.02) | 0.06 (0.03) | 0.02 (0.01) | 0.70 | |
| rs2857713 | −0.03 (0.01)e | −0.02 (0.02) | 0.001 (0.03) | −0.07 (0.04) | −0.03 (0.01)k | 0.38 | |
| rs1041981 | 0.05 (0.01)f | 0.003 (0.02) | 0.01 (0.02) | 0.06 (0.03) | 0.02 (0.01) | 0.51 | |
| rs1799964 | −0.03 (0.01)g | −0.02 (0.02) | 0.01 (0.03) | −0.07 (0.04) | −0.02 (0.01) | 0.65 | |
| rs1799724 | −0.03 (0.02) | −0.08 (0.04) | −0.01 (0.03) | 0.05 (0.04) | −0.002 (0.01) | 0.01 | |
| rs1800750 | 0.03 (0.04) | 0.04 (0.05) | 0.08 (0.08) | −0.35 (0.31) | 0.03 (0.03) | 0.93 | |
| rs1800629 | 0.04 (0.01)h | −0.01 (0.02) | 0.03 (0.04) | 0.01 (0.08) | 0.02 (0.01) | 0.07 | |
| rs361525 | −0.03 (0.02) | 0.02 (0.04) | −0.02 (0.06) | −0.09 (0.08) | −0.02 (0.02) | 0.58 | |
| rs3093661 | −0.04 (0.02) | −0.03 (0.04) | −0.08 (0.08) | −0.08 (0.08) | −0.05 (0.02) | 0.44 | |
| rs3093662 | −0.04 (0.02) | 0.01 (0.03) | −0.05 (0.05) | −0.10 (0.08) | −0.03 (0.01) | 0.44 | |
| rs769178 | −0.03 (0.02) | −0.07 (0.04) | −0.01 (0.03) | 0.04 (0.04) | −0.001 (0.01) | 0.02 | |
| rs2256974 | 0.04 (0.01)i | 0.01 (0.02) | 0.02 (0.03) | 0.05 (0.03) | 0.01 (0.01) | 0.54 | |
| IL-6 | (n=1,608) | (n=918) | (n=327) | (n=207) | (n=3,060) | ||
| rs1880242 | −0.01 (0.01) | −0.03 (0.03) | −0.06 (0.04) | −0.01 (0.05) | −0.01 (0.01) | 0.64 | |
| rs10499563 | −0.003 (0.01) | −0.003 (0.02) | 0.003 (0.03) | 0.02 (0.05) | −0.002 (0.01) | 0.69 | |
| rs2069824 | −0.01 (0.02) | −0.01 (0.03) | −0.02 (0.05) | −0.08 (0.09) | −0.01 (0.01) | 0.28 | |
| rs1800797 | −0.05 (0.03) | −0.05 (0.07) | −0.10 (0.08) | −0.28 (0.26) | −0.04 (0.02) | 0.02 | |
| rs1800796 | 0.03 (0.05) | 0.06 (0.07) | −0.10 (0.07) | 0.02 (0.10) | 0.04 (0.03) | 0.07 | |
| rs1800795 | −0.04 (0.03) | −0.05 (0.07) | −0.10 (0.08) | −0.23 (0.27) | −0.03 (0.02) | 0.01 | |
| rs2069830 | −0.32 (0.50) | 0.05 (0.07) | −0.06 (0.53) | ---j | 0.09 (0.06) | 0.62 | |
| rs2069838 | 0.05 (0.27) | 0.005 (0.08) | −0.36 (0.38) | ---j | 0.04 (0.07) | 0.57 | |
| rs2069840 | −0.01 (0.03) | 0.08 (0.05) | −0.17 (0.06) | −0.06 (0.17) | −0.01 (0.02) | 0.66 | |
| rs2069842 | −0.16 (0.27) | −0.05 (0.08) | 0.46 (0.26) | ---j | −0.08 (0.06) | 0.17 | |
| rs2069845 | 0.04 (0.03) | −0.001 (0.04) | 0.12 (0.07) | 0.10 (0.40) | 0.04 (0.02) | 0.01 | |
| rs2069861 | 0.05 (0.05) | 0.13 (0.15) | 0.21 (0.14) | ---j | 0.07 (0.04) | 0.04 | |
| rs1524106 | 0.03 (0.03) | 0.05 (0.04) | −0.01 (0.06) | −0.02 (0.15) | 0.03 (0.02) | 0.04 | |
| rs1524103 | −0.03 (0.03) | −0.03 (0.04) | −0.05 (0.07) | 0.002 (0.12) | −0.01 (0.02) | 0.50 | |
Difference in mean logarithms and standard error per additional reference allele of each SNP was calculated using general linear regression models with adjustment for matching factors (age, clinical center, and time of blood draw), incidence of diabetes, and other confounders including BMI, hormone replacement therapy, alcohol consumption, cigarette smoking, family history of diabetes, and physical activity.
P-value was estimated based on a log-likelihood ratio test for interaction between each genotype and ethnicity on plasma concentrations.
P-value was 0.003 with q-value = 0.01 after FDR.
P-value was 0.000041 with q-value = 0.0003 after FDR.
P-value was 0.005 with q-value = 0.02 after FDR.
P-value was 0.000006 with q-value < 0.0001 after FDR.
P-value was 0.007 with q-value = 0.02 after FDR.
P-value was 0.006 with q-value = 0.02 after FDR.
P-value was 0.004 with q-value = 0.01 after FDR.
Result is difficult to interpret because of small sample size within strata.
P-value was 0.0009 with q-value = 0.01 after FDR.