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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Clin Chem. 2010 Dec 13;57(2):317–325. doi: 10.1373/clinchem.2010.154526

Table 3.

The multivariable-adjusted odds ratio (95% CI) for diabetes risk associated with genetic variants using the additive effect model

Gene SNP ID Adjusted OR (95% CI)a
 P-value for ethnic interactionc
Whites Blacks Hispanics Asian/Pacific Islanders All
CRP (870/865)b (303/638) (115/242) (67/154) (1355/1899)
rs4275453 0.87(0.71–1.07) 0.85(0.67–1.09) 0.93(0.57–1.52) 1.04(0.51–2.15) 0.85(0.74–0.98)i 0.92
rs2808634 0.82(0.66–1.03) 0.74(0.51–1.07) 0.84(0.48–1.49) 1.93(0.73–5.11) 0.81(0.68–0.97)j 0.34
rs3093059 0.86(0.59–1.25) 1.17(0.88–1.56) 0.62(0.30–1.25) 0.76(0.32–1.80) 1.03(0.84–1.26) 0.38
rs2794521 0.82(0.65–1.02) 0.78(0.54–1.14) 0.76(0.41–1.38) 1.66(0.66–4.19) 0.81(0.68–0.97)k 0.43
rs1417938 1.03(0.84–1.28) 1.36(0.93–2.00) 1.07(0.65–1.76) 0.75(0.23–2.47) 1.09(0.92–1.28) 0.91
rs1800947 1.25(0.85–1.84) 0.52(0.15–1.81) 1.46(0.40–5.31) 1.00(0.33–2.96) 1.18(0.86–1.63) 0.55
rs1130864 1.09(0.88–1.35) 1.18(0.86–1.63) 0.91(0.56–1.48) 1.15(0.40–3.31) 1.09(0.93–1.28) 0.76
rs1205 1.10(0.89–1.37) 0.80(0.59–1.10) 1.19(0.74–1.92) 0.82(0.43–1.56) 1.01(0.86–1.17) 0.61
rs3093075 0.90(0.61–1.32) 1.17(0.88–1.55) 0.57(0.28–1.16) 1.09(0.47–2.51) 1.06(0.87–1.31) 0.76
rs3093068 0.81(0.59–1.13) 1.30(0.97–1.73) 0.84(0.42–1.66) 1.11(0.47–2.61) 1.05(0.86–1.28) 0.62
rs2808629 1.15(0.93–1.43) 0.73(0.54–0.99)d 1.30(0.81–2.10) 0.72(0.39–1.35) 1.00(0.86–1.16) 0.34
rs2369146 0.79(0.62–1.00) 0.96(0.74–1.24) 1.23(0.76–2.00) 2.19(0.80–5.97) 0.92(0.78–1.08) 0.02l
rs1470515 1.21(0.99–1.48) 0.70(0.52–0.94)e 0.97(0.62–1.53) 0.95(0.50–1.83) 1.01(0.87–1.17) 0.29
TNF-α (867/882) (306/638) (115/244) (68/155) (1356/1919)
rs2239705 1.02(0.79–1.31) 0.74(0.50–1.09) 0.96(0.61–1.53) 0.75(0.31–1.79) 0.92(0.76–1.10) 0.39
rs2230365 1.06(0.81–1.40) 0.91(0.53–1.54) 0.77(0.42–1.44) 0.86(0.47–1.55) 0.96(0.78–1.17) 0.79
rs2009658 0.96(0.73–1.27) 0.90(0.60–1.33) 0.75(0.42–1.33) 0.92(0.44–1.94) 0.92(0.76–1.11) 0.75
rs2239704 1.09(0.90–1.31) 0.79(0.59–1.07) 1.33(0.92–1.92) 0.66(0.35–1.23) 1.00(0.88–1.15) 0.36
rs909253 0.99(0.81–1.21) 1.40(1.06–1.85) 0.83(0.54–1.28) 1.77(0.92–3.38) 1.09(0.95–1.25) 0.52
rs2857713 0.84(0.67–1.05) 0.94(0.70–1.27) 0.90(0.55–1.46) 0.97(0.50–1.91) 0.90(0.77–1.05) 0.27
rs1041981 1.02(0.83–1.24) 1.39(1.06–1.83) 0.84(0.55–1.28) 1.79(0.93–3.43) 1.11(0.97–1.28) 0.60
rs1799964 0.89(0.70–1.13) 0.86(0.61–1.20) 1.01(0.60–1.72) 1.01(0.50–2.03) 0.91(0.76–1.07) 0.28
rs1799724 1.04(0.76–1.43) 0.62(0.30–1.28) 1.14(0.67–1.94) 0.80(0.34–1.92) 0.97(0.77–1.23) 0.57
rs1800750 0.51(0.24–1.09) 1.22(0.55–2.69) 2.58(0.55–12.2) ---g 0.90(0.54–1.50) 0.01m
rs1800629 0.91(0.70–1.18) 1.24(0.86–1.78) 1.19(0.56–2.52) 6.29(1.14–34.8)h 1.04(0.85–1.27) 0.02n
rs361525 0.74(0.49–1.11) 1.04(0.57–1.87) 2.23(0.77–6.46) 1.56(0.39–6.17) 0.93(0.69–1.26) 0.09
rs3093661 0.79(0.50–1.26) 0.66(0.33–1.32) 1.56(0.44–5.50) 0.48(0.08–2.92) 0.79(0.56–1.12) 0.95
rs3093662 0.87(0.62–1.23) 0.70(0.43–1.12) 1.09(0.47–2.52) 1.24(0.33–4.63) 0.84(0.66–1.08) 0.61
rs769178 1.06(0.77–1.47) 0.58(0.28–1.20) 1.09(0.64–1.86) 0.94(0.39–2.27) 0.98(0.77–1.24) 0.70
rs2256974 1.10(0.85–1.42) 1.26(0.96–1.67) 0.80(0.49–1.30) 1.49(0.76–2.93) 1.14(0.97–1.34) 0.71
IL-6 (876/888) (304/641) (115/244) (67/154) (1362/1927)
rs1880242 1.01 (0.90–1.13) 1.04 (0.89–1.22) 1.14 (0.74–1.76) 1.14 (0.81–1.60) 1.03 (0.95–1.12) 0.36
rs10499563 0.97 (0.88–1.08) 0.96 (0.83–1.11) 0.97 (0.76–1.23) 0.80 (0.58–1.11) 0.95 (0.89–1.03) 0.36
rs2069824 0.93 (0.81–1.08) 1.06 (0.89–1.27) 0.66 (0.45–0.98)f ---g 0.98 (0.89–1.09) 0.57
rs1800797 1.10 (0.90–1.34) 0.84 (0.57–1.26) 1.12 (0.62–2.04) 0.66 (0.09–4.77) 1.04 (0.89–1.23) 0.82
rs1800796 1.18 (0.79–1.76) 1.34 (0.88–2.04) 1.02 (0.60–1.73) 0.90 (0.52–1.55) 1.10 (0.89–1.37) 0.66
rs1800795 1.06 (0.87–1.29) 0.93 (0.61–1.41) 1.35 (0.76–2.41) 0.31 (0.01–6.92) 1.05 (0.89–1.23) 0.77
rs2069830 1.81 (0.09–38.7) 0.99 (0.62–1.56) ---g ---g 1.00 (0.64–1.57) 0.66
rs2069838 0.76 (0.15–3.88) 1.22 (0.76–1.97) ---g ---g 1.08 (0.69–1.69) 0.76
rs2069840 1.16 (0.93–1.43) 0.89 (0.65–1.23) 0.94 (0.61–1.44) 0.64 (0.24–1.69) 1.06 (0.91–1.23) 0.28
rs2069842 1.07 (0.11–10.4) 1.43 (0.87–2.37) 1.07 (0.14–8.55) ---g 1.26 (0.79–2.02) 0.98
rs2069845 0.91 (0.75–1.11) 1.13 (0.87–1.48) 0.82 (0.51–1.32) ---g 0.95 (0.82–1.09) 0.49
rs2069861 0.88 (0.62–1.25) 1.12 (0.43–2.91) 1.16 (0.43–3.16) ---g 0.98 (0.73–1.33) 0.92
rs1524106 0.86 (0.70–1.06) 1.13 (0.88–1.44) 0.87 (0.58–1.31) 0.97 (0.40–2.34) 0.95 (0.83–1.10) 0.53
rs1524103 1.17 (0.93–1.47) 0.94 (0.73–1.20) 1.16 (0.73–1.85) 0.75 (0.38–1.47) 1.02 (0.88–1.18) 0.33
a

Odds Ratio (OR) per additional reference allele of each SNP was calculated for additive genetic effect model; ORs were estimated using conditional logistic regression models adjusted for matching factors (age, clinical center, time of blood draw, and ethnicity), BMI, cigarette smoking, alcohol intake, hormone replacement therapy, family history of diabetes and physical activity.

b

Sample size for each ethnic group was shown for each plasma marker in the format of (cases/controls).

c

P-value was estimated based on a log-likelihood ratio test for interaction between each genotype and ethnicity on diabetes risk.

d

P-value was 0.04 with q-value = 0.28 after FDR.

e

P-value was 0.02 with q-value = 0.25 after FDR.

f

P-value was 0.04 with q-value = 0.56 after FDR.

g

Result was difficult to interpret because of small sample size within strata.

h

P-value was 0.04 with q-value = 0.46 after FDR.

i

P-value was 0.03 with q-value = 0.12 after FDR.

j

P-value was 0.02 with q-value = 0.12 after FDR.

k

P-value was 0.02 with q-value = 0.12 after FDR.

l

The P-value became 0.24 after FDR.

m

The P-value became 0.15 after FDR.

n

The P-value became 0.15 after FDR.