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Published in final edited form as: Free Radic Biol Med. 2007 Oct 3;44(6):972–981. doi: 10.1016/j.freeradbiomed.2007.09.013

Fig.1 — A. Paw withdrawal latencies in response to radiant heat and tail-flick test response latencies in control and diabetic mice with or without the PARP inhibitor GPI-15427 treatment. Mean ± SEM, n = 6–12 per group. C – control rats, D - diabetic rats. T- GPI-15427 treatment. ** – p < 0.01 vs non-diabetic control rats; ^{#, ##} – p < 0.05 and < 0.01 vs untreated diabetic rats. B. Paw withdrawal latencies in response to radiant heat and tail-flick test response latencies in control and diabetic PARP+/+ and PARP−/− mice. Mean ± SEM, n = 13–18 per group. C – control mice, D - diabetic mice. ** – p < 0.01 vs non-diabetic control mice; ^## – p < 0.01 vs diabetic wild-type mice. C. Mechanical withdrawal thresholds in rigid von Frey filament test and paw-pressure Randall-Selitto test in control and diabetic rats with or without the PARP inhibitor GPI-15427 treatment. Mean ± SEM, n = 6–12 per group. C – control rats, D – diabetic rats. T - GPI-15427 treatment. ** – p < 0.01 vs control rats; ^{#, ##} – p < 0.05 and < 0.01 vs untreated diabetic rats. D. Mechanical withdrawal thresholds in tail-pressure Randall-Selitto test in control and diabetic PARP+/+ and PARP−/− mice. Mean ± SEM, n = 13–18 per group. C – control mice, D - diabetic mice. ** – p < 0.01 vs non-diabetic control mice; ^## – p < 0.01 vs diabetic wild-type mice. E. Left - tactile response thresholds in flexible von Frey filament test (left) in control and diabetic rats with or without the PARP inhibitor GPI-15427 treatment. Mean ± SEM, n = 6–12 per group. C – control rats, D – diabetic rats. T - GPI-15427 treatment. ** – p < 0.01 vs control rats; ^## – p < 0.01 vs untreated diabetic rats. Right - tactile response thresholds in flexible von Frey filament test in control and diabetic PARP+/+ and PARP−/− mice. Mean ± SEM, n = 13–18 per group. C – control mice, D - diabetic mice. ** – p < 0.01 vs non-diabetic control mice; ^## – p < 0.01 vs diabetic wild-type mice.

Fig.1 — A. Paw withdrawal latencies in response to radiant heat and tail-flick test response latencies in control and diabetic mice with or without the PARP inhibitor GPI-15427 treatment. Mean ± SEM, n = 6–12 per group. C – control rats, D - diabetic rats. T- GPI-15427 treatment. ** – p < 0.01 vs non-diabetic control rats; ^{#, ##} – p < 0.05 and < 0.01 vs untreated diabetic rats. B. Paw withdrawal latencies in response to radiant heat and tail-flick test response latencies in control and diabetic PARP+/+ and PARP−/− mice. Mean ± SEM, n = 13–18 per group. C – control mice, D - diabetic mice. ** – p < 0.01 vs non-diabetic control mice; ^## – p < 0.01 vs diabetic wild-type mice. C. Mechanical withdrawal thresholds in rigid von Frey filament test and paw-pressure Randall-Selitto test in control and diabetic rats with or without the PARP inhibitor GPI-15427 treatment. Mean ± SEM, n = 6–12 per group. C – control rats, D – diabetic rats. T - GPI-15427 treatment. ** – p < 0.01 vs control rats; ^{#, ##} – p < 0.05 and < 0.01 vs untreated diabetic rats. D. Mechanical withdrawal thresholds in tail-pressure Randall-Selitto test in control and diabetic PARP+/+ and PARP−/− mice. Mean ± SEM, n = 13–18 per group. C – control mice, D - diabetic mice. ** – p < 0.01 vs non-diabetic control mice; ^## – p < 0.01 vs diabetic wild-type mice. E. Left - tactile response thresholds in flexible von Frey filament test (left) in control and diabetic rats with or without the PARP inhibitor GPI-15427 treatment. Mean ± SEM, n = 6–12 per group. C – control rats, D – diabetic rats. T - GPI-15427 treatment. ** – p < 0.01 vs control rats; ^## – p < 0.01 vs untreated diabetic rats. Right - tactile response thresholds in flexible von Frey filament test in control and diabetic PARP+/+ and PARP−/− mice. Mean ± SEM, n = 13–18 per group. C – control mice, D - diabetic mice. ** – p < 0.01 vs non-diabetic control mice; ^## – p < 0.01 vs diabetic wild-type mice.