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. Author manuscript; available in PMC: 2011 Mar 15.
Published in final edited form as: J Immunol. 2008 Sep 15;181(6):4381–4388. doi: 10.4049/jimmunol.181.6.4381

FIGURE 2.

FIGURE 2

4-1BBL enhances beryllium-specific CD4+ T cell proliferation. A, Adenovirus-infected HLA-DP2-expressing DAP.3 L cells express B7.1, OX-40L, or 4-1BBL. HLA-DP2-expressing fibroblasts were infected with replication-defective adenoviruses (MOI of 50) containing no transgene, B7.1, OX-40L, or 4-1BBL. Twenty-four hours after infection, the surface levels of B7.1, OX-40L, and 4-1BBL were assessed by flow cytometry. B, Proliferation of an HLA-DP2-restricted CD4+ T cell line to 100 μM BeSO4 presented by DP2-expressing DAP.3 L cells with and without the expression of B7.1, OX-40L, or 4-1BBL is shown. A representative example of three separate experiments is shown, and data are expressed as the mean cpm ± SEM.