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. Author manuscript; available in PMC: 2011 Mar 15.
Published in final edited form as: Chembiochem. 2007 Mar 5;8(4):373–378. doi: 10.1002/cbic.200600473

Scheme 4.

Scheme 4

Src kinase phosphorylates peptide 8 to create biosensor 9 in situ. A pyrene analogue of the latter gives a sevenfold fluorescent response upon binding to an SH2 domain. (Adapted from ref. [15].)