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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Jan 7;21(5):1472–1475. doi: 10.1016/j.bmcl.2011.01.004

Figure 1.

Figure 1

(a) Crystal structure of PDI bound to Mdm2 (PDB code: 3G03) and Mdmx (PDB code: 3FDO). The proteins were rendered in surface model and PDI was shown in ribbon and tube model. The side chains of three canonical residues, F3, W7 and L10, were shown in blue. (b) Helical wheel diagram of PDI viewed from the N- to C-terminus. The five possible stapling sites were colored in red. The pyrazoline cross-linker structure formed after the cycloaddition reaction is shown on the right.