Table 1.
Demographic characteristics of Parkinson disease (PD) cases, sibling controls, and unrelated controls
| Cases-sibling control pairs | Cases-unrelated control pairs | All cases and controls | ||||
|---|---|---|---|---|---|---|
| PD Cases | Sibling Controls | PD Cases | Unrelated Controls | Cases | Controls | |
| Total sample, n | 514 | 514 | 379 | 379 | 893 | 893 |
| Men, n (%) | 323 (62.8) | 256 (49.8) | 234 (61.7) | 234 (61.7) | 557 (62.4) | 490 (54.9) |
| Women, n (%) | 191 (37.2) | 258 (50.2) | 145 (38.3) | 145 (38.3) | 336 (37.6) | 403 (45.1) |
| Age at onset of PD, median (range) | 60.2 (29.4–86.9) | -- | 65.1 (23.3–88.0) | -- | 62.1 (23.3–88.0) | -- |
| Age at study, median (range)a | 66.1 (32.8–91.4) | 64.8 (32.0–90.4) | 70.4 (42.3–90.4) | 71.3 (44.9–92.8) | 67.9 (32.8–91.4) | 67.2 (32.0–92.8) |
| Region of origin of parents, n (%)b | ||||||
| Both parents of European origin | 447 (87.0) | 435 (84.6) | 302 (79.7) | 330 (97.1) | 749 (83.9) | 765 (85.7) |
| Only one parent of European originc | 40 (7.8) | 47 (9.1) | 54 (14.2) | 33 (8.7) | 94 (10.5) | 80 (9.0) |
| One parent declared “American”d | 17 (3.3) | 16 (3.1) | 20 (5.3) | 15 (4.0) | 37 (4.1) | 31 (3.5) |
| Both parents declared “American”d | 18 (3.5) | 18 (3.5) | 12 (3.2) | 7 (1.8) | 30 (3.4) | 25 (2.8) |
| Both parents Asian | 1 (0.2) | 2 (0.4) | 3 (0.8) | 0 (0.0) | 4 (0.4) | 2 (0.2) |
| Both parents Mexican | 1 (0.2) | 1 (0.2) | 0 (0.0) | 1 (0.3) | 1 (0.1) | 2 (0.2) |
| Both parents African | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Unknown | 5 (1.0) | 10 (1.9) | 7 (1.8) | 4 (1.1) | 12 (1.3) | 14 (1.6) |
a
Age at blood draw
b
Self-reported by subjects
c
Includes subjects for whom origin of one parent is unknown
d
These subjects were all Caucasians and not Native Americans