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. 2011 Feb 1;6:6. doi: 10.1186/1749-8104-6-6

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Copyright ©2011 Rosenbaum et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Basal and intermediate progenitors of OE express Insm1 mRNA. (A) In situ hybridization (ISH) on a coronal section of an E17.5 mouse embryo head reveals Insm1 in basal and intermediate, but not apical, cells of the OE. Subventricular cells of the olfactory bulb (OB) also express Insm1. (B, C) ISH for Insm1 (B) combined with immunohistochemistry for the cell-division marker Ki67 (C) on the same coronal sections of E14.5 OE demonstrates Insm1 expression in few apical (empty arrows) and most intermediate and basal cells. While most apical progenitors (Ki67-positive) do not express Insm1 (arrowheads), intermediate and basal cells in division do express Insm1 (filled arrows). (D, E) ISH for Insm1 (D) combined with immunohistochemistry for the mitotic marker pH3 (E) on the same coronal sections of E12.5 OE demonstrates Insm1 expression in few apical (empty arrows) and most intermediate and basal cells. While most apical progenitors in mitosis do not express Insm1 (arrowheads), intermediate and basal progenitors in mitosis do express Insm1 (filled arrows).