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. Author manuscript; available in PMC: 2011 Mar 15.
Published in final edited form as: Exp Biol Med (Maywood). 2010 May;235(5):633–641. doi: 10.1258/ebm.2009.009229

Fig. 2. DFO inhibits LPS-induced NFκB and AP-1 activation in aorta of C57BL/6J mice.

Fig. 2

Mice were injected i.p. with vehicle HBSS (daily x 14 days), DFO (100 mg/kg b.w. daily x 14 days), 50 μg LPS, or LPS+DFO as described in Methods. Three hours after HBSS or LPS injection, the animals were sacrificed and nuclear extracts were isolated from aorta. NFκB (p65)/DNA (A) and AP-1 (c-fos)/DNA (B) binding activities were quantified by ELISA. Data shown are mean values ± SEM of five animals per group. #P<0.01 compared to control HBSS-treated animals and *P<0.05 compared to LPS-treated animals.