Table 1.
Demographic and clinical characteristics of patients admitted in ICU
| Variable | H1N1- (n = 45) | H1N1+ (n = 61) | P value |
|---|---|---|---|
| Age (years) | 42.8 ± 18.1 | 34.2 ± 12.9 | 0.005* |
| Gender, Male | 24 (53) | 31 (50.8) | 0.80 |
| GCS on admission | 10.4 ± 4.6 | 10.7 ± 4.7 | 0.78 |
| Duration of illness (days) | 5.6 ± 3.2 | 5.7 ± 3.1 | 0.82 |
| SOFA score | |||
| SOFA (Day 1) | 6.6 ± 3.1 | 7.8 ± 3.5 | 0.08 |
| SOFA (Day 3) | 6.5 ± 3.1 | 7.2 ± 4.5 | 0.43 |
| PaO2:FiO2 | 114 ± 51.7 | 87.3 ± 48.7 | 0.008* |
| PaO2 at time of intubation (mm Hg) | 49.6 ± 11.4 | 45.1 ± 14.0 | 0.08 |
| Hypotension at time of admission | 8 (17.8) | 8 (13.1) | 0.51 |
| Adverse events | |||
| 1. Refractory hypoxia | 12 (26) | 27 (44.2) | 0.04* |
| 2. Acidosis (pH < 7.1) | 9 (20) | 18 (29.5) | 0.27 |
| 3. Inotropic requirement during ICU stay | |||
| Single inotrope | 6 (13.3) | 11 (18.0) | 0.20 |
| Double inotrope | 11 (24.4) | 13 (21.3) | 0.70 |
| 4. ARF | 4 (8.8) | 16 (26.2) | 0.02* |
| 5. MODS | 5 (11.1) | 12 (19.6) | 0.24 |
| 6. DIC | 5 (11.1 | 3 (0.05) | 0.23 |
| Laboratory investigations | |||
| Total leucocyte count (TLC) | |||
| TLC -Day 1 (cells/mm3) | 22,450 ± 7,648 | 9,750 ± 6,122 | 0.001* |
| TLC -Day 2 (cells/mm3) | 18,150 ± 7,868 | 12,050 ± 6,666 | 0.008* |
| TLC -Day 3 (cells/mm3) | 24,400 ± 6,002 | 10,650 ± 4,067 | 0.001* |
| TLC -Day 4 (cells/mm3) | 20,000 ± 7,980 | 12,000 ± 7,7737 | 0.048* |
| Anaemia | 5 (11.1) | 12 (19.7) | 0.24 |
| Thrombocytopenia | 6 (13.3) | 9 (14.8) | 0.84 |
Values are mean ± SD or n (%) P ≤ 0.05 was considered statistically significant. GCS: Glasgow Coma Scale; ICU: Intensive care unit; SOFA: Sequential organ failure assessment; DIC: Disseminated intravascular coagulation; ARF: Acute renal failure; MODS: Multiple organ dysfunction syndrome; TLC: Total leucocyte count