Figure 4.
Effect of phospho-non-steroidal anti-inflammatory drugs (NSAIDs) on PGE2. (A) PGE2 levels in NIH 3T3 cells pre-treated with 1.5 × IC50 phospho-aspirin (P-A), aspirin (ASA), phospho-ibuprofen (P-I) and phospho-sulindac (P-S) for 30 min followed by treatment with A23187 5 µM for 3 h. Values are mean ± standard deviation of three independent experiments; #significantly different compared with control non-stimulated group, P < 0.05; *significantly different compared with A23187-stimulated group; P < 0.01. (B) PGE2 levels was measured by elisa in rat plasma from normal or FA/vehicle-treated rats, or rats treated with phospho-aspirin (110 mg·kg−1·day−1) or aspirin (35 mg·kg−1·day−1) for 18 days. Values are mean ± SEM (n= 5); *significantly different compared with FA/vehicle-treated group; P < 0.05).