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Endothelium-dependent relaxations induced by (A) acetylcholine, (B) A23187, (C) UK14304 (acting on α2-adrenoceptors on the endothelium) and endothelium-independent relaxations, (D) induced by sodium nitroprusside of U46619-contracted rings in aortae of age-matched wild-type (C57) and apolipoprotein E-deficient (ApoE−/−) mice at 8, 12 and 18 weeks old. Data are shown as means ± SEM *P < 0.05; **P < 0.01 compared with the control of age-matched C57 mice. n= 6–8.
