Table 2.

EC₅₀ values and maximal relaxations of aortic rings

Max. relaxation EC50	WT 8 weeks	ApoE−/− 8 weeks	WT 12 weeks	ApoE−/− 12 weeks	WT 18 weeks	ApoE−/− 18 weeks	ApoE−/− 18 weeks + BMS
UK14304	95.07 ± 1.46	75.56 ± 0.00***	92.55 ± 4.74	69.61 ± 4.40***	90.80 ± 0.97	66.22 ± 4.66**	87.82 ± 2.99†
	−8.27 ± 0.27	−7.17 ± 0.0*	−7.77 ± 0.19	−6.75 ± 0.37*	−7.77 ± 0.09	−6.76 ± 0.25*	−7.76 ± 0.18†
Ach	87.01 ± 0.97	63.06 ± 9.57***	90.53 ± 2.76	78.12 ± 3.35***	84.39 ± 1.89	68.01 ± 4.91***	90.49 ± 2.57†
	−6.73 ± 0.12	−5.71 ± 0.51***	−6.86 ± 0.16	−6.45 ± 0.08*	−6.64 ± 0.18	−5.95 ± 0.22*	−7.01 ± 0.11†
A23187	69.88 ± 7.50	88.15 ± 3.59 ns	69.42 ± 3.41	84.54 ± 4.48*	65.45 ± 3.26	62.73 ± 8.16 ns	68.19 ± 7.67 ns
	−7.14 ± 0.34	−7.00 ± 0.09 ns	−6.85 ± 0.11	−6.90 ± 0.04 ns	−6.87 ± 0.13	−6.34 ± 0.11*	−6.87 ± 0.19†
SNP	99.51 ± 1.43	99.23 ± 1.76 ns	95.29 ± 0.81	95.77 ± 0.53 ns	95.13 ± 1.79	76.94 ± 17.47 ns	96.98 ± 1.34 ns
	−7.72 ± 0.12	−7.77 ± 0.17 ns	−7.28 ± 0.14	−7.41 ± 0.07 ns	−7.27 ± 0.17	−7.66 ± 0.09 ns	−7.88 ± 0.15 n.s.

The EC₅₀ values (log M) and maximal relaxation (%) in response to various endothelium-dependent vasodilators [UK14304, acetylcholine (ACh), A23187 and sodium nitroprusside (SNP)] in wild-type mice (8 to 18 weeks of age), ApoE^−/− (8 to 18weeks of age) and ApoE^−/− mice with chronic treatment (18 weeks of age; ApoE^−/− 18 wk + BMS) for 6 weeks. Data are shown in parallel for age-matched C57 mice. Data are shown as means ± SEM

^*P < 0.05;

^**P < 0.01;

^***P < 0.000 compared with the wild-type control.

^†P < 0.01; compared with the ApoE^−/− mice without BMS309403 treatment. ns not significant. n= 5–7.