Table 2.
Time to detection of transfected parasites under selection with atovaquone or DSM1
| Construct | Atovaquone selection (in weeksa) | DSM1 selection (in weeksa) |
|---|---|---|
| pUF-1/ΔAMT1 | 5 | 4 |
| pUF-1/ΔCSP | 6 | 4 |
| pUF-1/ΔRPL2 | 6 | 4 |
| pUF-1/ΔMQO | 8 | 3 |
| pUF-1/ΔRNAPOL* | 4 | 2 |
| pUF-1/ΔNDH2* | 5 | 3 |
| pUF-1/ΔDHODH* | 5 | 2 |
| pUF-1/ΔG3PDH* | 5 | 3 |
| Average difference | −2.4 | |
a
Weeks following transfection when the transgenic parasites were observed in Giemsa stained smears.
*
Indicates experiments in which a single transfection was split into two flasks, each of which was placed under selection by a different one of the inhibitors.