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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: J Mol Cell Cardiol. 2010 Dec 30;50(4):652–661. doi: 10.1016/j.yjmcc.2010.12.015

Fig. 2.

Fig. 2

Functional domains and expression of Abro1 mRNA in human tissues. (A) Schematic representation of the different domains of Abro1 protein. The protein can be divided into three functionally and structurally distinct domains. The amino-terminal ABR domain has been previously shown to mediate interaction with BRE and NBA1 proteins. The coiled-coil (c-c) domain has also been shown to interact with BRCC36. The carboxyl-terminal domain of Abro1 (targeting domain) is unique in its amino acid sequence and interacts with THAP5. (B) A commercially available Northern blot (Clontech) containing 2μg/lane poly mRNA from various adult human tissues was probed with 32P-Abro1 cDNA. A single transcript of about 3.0 kb long was detected. Abro1 is predominantly expressed in the heart although some expression is also seen in muscle, brain, kidney, and small intestine. β-actin probe was used to verify that equal amounts of mRNA were present in each lane.