Table 2.
Difference in mean gestational length and odds ratios (95% CI) for preterm birth by DES exposure status, cohort, and dose and gestational age of first exposure to DES
| Gestational Length1(week) | Preterm birth (<37 weeks) | |||
|---|---|---|---|---|
| N | β (95% CI) | N (%) | OR (95% CI) | |
| Combined cohorts | ||||
| Unexposed | 1386 | Ref | 66 (4.8) | 1.00 |
| Exposed | 3713 | −0.63 (−0.78, −0.49)2 | 511 (13.8) | 2.97 (2.27, 3.87)2 |
| Dieckmann cohort | ||||
| Unexposed | 369 | Ref | 15 (4.1) | 1.00 |
| Exposed | 400 | −0.51 (−0.84, −0.17) | 31 (7.8) | 1.98 (1.05,3.74) |
| DESAD cohort | ||||
| Unexposed | 1017 | Ref | 51 (5.0) | 1.00 |
| Exposed | 3313 | −0.66 (−0.82, −0.51) | 480 (14.6) | 3.22 (2.39,4.33) |
| Low dose cohort | 1607 | −0.43 (−0.60, −0.26) | 206 (12.8) | 2.54(1.90,3.40) |
| High dose cohort | 2085 | −0.77 (−0.92, −0.61) | 305 (14.6) | 3.29 (2.45,4.33) |
| Cumulative dose of DES (mg)3,4 | ||||
| Unexposed | 1017 | Ref | 51 (5.0) | 1.00 |
| <2500 | 384 | −0.47 (−0.72, −0.22) | 46 (12.0) | 2.56 (1.69,3.89) |
| 2500–9999 | 415 | −0.99 (−1.23, −0.74) | 73 (17.6) | 4.02 (2.75,5.87) |
| 10,000+ | 367 | −0.90 (−1.16, −0.64) | 72 (19.6) | 4.60 (3.14,6.74) |
| Gestational age at first exposure to DES (weeks)4 | ||||
| Unexposed | 1017 | Ref | 51 (5.0) | 1.00 |
| ≤ 7 | 901 | −0.98 (−1.19, −0.78) | 166 (18.4) | 4.25 (3.06,5.91) |
| 8–10 | 806 | −0.60 (−0.81, −0.40) | 103 (12.8) | 2.76 (1.95,3.91) |
| 11–14 | 617 | −0.50 (−0.72, −0.28) | 81 (13.1) | 2.85 (1.97,4.10) |
| 15+ | 808 | −0.49 (−0.70, −0.28) | 106 (13.1) | 2.84 (2.01,4.03) |
1
757 observations with missing gestational age and 26 outliers (gestational age > 45 weeks) excluded
2
Adjusted for cohort
3
2094 observations with unknown cumulative dose excluded
4
DESAD cohort only