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. Author manuscript; available in PMC: 2012 Feb 16.
Published in final edited form as: Tetrahedron Lett. 2011 Feb 16;52(7):817–819. doi: 10.1016/j.tetlet.2010.12.043

Table 1.

RGD-Containing Cyclic Peptides

graphic file with name nihms264247t1.jpg
RGD analog Observed MW Purity (%)a Yieldb
5a -Arg-Gly-Asp- 544.6 (MH+) 81 45
5b -Arg-Gly-Asp-Tyr- 707.9 (MH+) 83 42
5c -Arg-Gly-Asp-Phe- 691.7 (MH+) 80 41
5d -Arg-Gly-Asp-Leu- 657.7 (MH+) 76 38
5e -Tyr-Arg-Gly-Asp- 707.7 (MH+) 84 43
5f -Phe-Arg-Gly-Asp- 691.7 (MH+) 82 44
5g -Leu-Arg-Gly-Asp- 657.7 (MH+) 84 42
5h -Arg-Gly-Asp-Tyr-Tyr- 870.9 (MH+) 82 40
5i -Arg-Gly-Asp-Phe-Tyr- 854.9 (MH+) 85 47
5j -Arg-Gly-Asp-Leu-Tyr- 820.9 (MH+) 78 41
5k -Arg-Gly-Asp-Tyr-Phe- 854.9 (MH+) 86 43
5l -Arg-Gly-Asp-Phe-Phe- 838.9 (MH+) 88 45
5m -Arg-Gly-Asp-Leu-Phe- 804.9 (MH+) 85 42
5n -Arg-Gly-Asp-Tyr-Leu- 820.9 (MH+) 79 40
5o -Arg-Gly-Asp-Phe-Leu- 804.9 (MH+) 82 39
5p -Arg-Gly-Asp-Leu-Leu- 770.9 (MH+) 84 43
5q -Tyr-Tyr-Arg-Gly-Asp- 870.9 (MH+) 80 41
5r -Phe-Tyr-Arg-Gly-Asp- 854.9 (MH+) 83 44
5s -Leu-Tyr-Arg-Gly-Asp- 820.9 (MH+) 81 42
5t -Leu-Phe-Arg-Gly-Asp- 854.9 (MH+) 77 39
5u -Phe-Phe-Arg-Gly-Asp- 838.9 (MH+) 79 41
5v -Leu-Phe-Arg-Gly-Asp- 804.9 (MH+) 80 43
5w -Tyr-Leu-Arg-Gly-Asp- 820.9 (MH+) 74 35
5x -Phe-Leu-Arg-Gly-Asp- 804.9 (MH+) 81 40
5y -Leu-Leu-Arg-Gly-Asp- 769.9 (MH+) 82 44
(a)

The products were run on a Vydac column, gradients 5 to 95% formic acid (0.1%) in ACN in 10 min. The purity was estimated on analytical traces at λ= 214 nm and 254 nm.

(b)

Yields are based on the amount of isolated purified products and are relative to the initial loading of the resin.