Table 1.
| ||||
---|---|---|---|---|
RGD analog | Observed MW | Purity (%)a | Yieldb | |
5a | -Arg-Gly-Asp- | 544.6 (MH+) | 81 | 45 |
5b | -Arg-Gly-Asp-Tyr- | 707.9 (MH+) | 83 | 42 |
5c | -Arg-Gly-Asp-Phe- | 691.7 (MH+) | 80 | 41 |
5d | -Arg-Gly-Asp-Leu- | 657.7 (MH+) | 76 | 38 |
5e | -Tyr-Arg-Gly-Asp- | 707.7 (MH+) | 84 | 43 |
5f | -Phe-Arg-Gly-Asp- | 691.7 (MH+) | 82 | 44 |
5g | -Leu-Arg-Gly-Asp- | 657.7 (MH+) | 84 | 42 |
5h | -Arg-Gly-Asp-Tyr-Tyr- | 870.9 (MH+) | 82 | 40 |
5i | -Arg-Gly-Asp-Phe-Tyr- | 854.9 (MH+) | 85 | 47 |
5j | -Arg-Gly-Asp-Leu-Tyr- | 820.9 (MH+) | 78 | 41 |
5k | -Arg-Gly-Asp-Tyr-Phe- | 854.9 (MH+) | 86 | 43 |
5l | -Arg-Gly-Asp-Phe-Phe- | 838.9 (MH+) | 88 | 45 |
5m | -Arg-Gly-Asp-Leu-Phe- | 804.9 (MH+) | 85 | 42 |
5n | -Arg-Gly-Asp-Tyr-Leu- | 820.9 (MH+) | 79 | 40 |
5o | -Arg-Gly-Asp-Phe-Leu- | 804.9 (MH+) | 82 | 39 |
5p | -Arg-Gly-Asp-Leu-Leu- | 770.9 (MH+) | 84 | 43 |
5q | -Tyr-Tyr-Arg-Gly-Asp- | 870.9 (MH+) | 80 | 41 |
5r | -Phe-Tyr-Arg-Gly-Asp- | 854.9 (MH+) | 83 | 44 |
5s | -Leu-Tyr-Arg-Gly-Asp- | 820.9 (MH+) | 81 | 42 |
5t | -Leu-Phe-Arg-Gly-Asp- | 854.9 (MH+) | 77 | 39 |
5u | -Phe-Phe-Arg-Gly-Asp- | 838.9 (MH+) | 79 | 41 |
5v | -Leu-Phe-Arg-Gly-Asp- | 804.9 (MH+) | 80 | 43 |
5w | -Tyr-Leu-Arg-Gly-Asp- | 820.9 (MH+) | 74 | 35 |
5x | -Phe-Leu-Arg-Gly-Asp- | 804.9 (MH+) | 81 | 40 |
5y | -Leu-Leu-Arg-Gly-Asp- | 769.9 (MH+) | 82 | 44 |
The products were run on a Vydac column, gradients 5 to 95% formic acid (0.1%) in ACN in 10 min. The purity was estimated on analytical traces at λ= 214 nm and 254 nm.
Yields are based on the amount of isolated purified products and are relative to the initial loading of the resin.