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. Author manuscript; available in PMC: 2012 Feb 17.
Published in final edited form as: Cell Host Microbe. 2011 Feb 17;9(2):147–157. doi: 10.1016/j.chom.2011.01.005

Figure 7. Model for PFT pore removal by RAB-5 and RAB-11-dependent endo- and exocytosis.

Figure 7

Microvilli containing PFT pores (red) are expelled from the apical cell surface through RAB-11-dependent vertex fusion (indicated with “V”) or some other mechanism. RAB-5-dependent endocytosis supports this process by maintaining membrane homeostasis through increased endocytosis (indicated by green arrow). Alternatively or in addition, pores are taken up from the plasma membrane into the cells by RAB-5-controlled endocytosis, and potentially transported to lysosomes. RAB-11-controlled exocytosis may balance increased endocytosis (indicated by green arrow).