Table 3.

In vitro selected antibodies recognizing cell surface receptors

Target	Notes/therapeutic indication	Ref
Blys	Systemic lupus erythematosis	102
Tumor necrosis factor a	Phage display was used to convert a murine mAb into a human antibody by guided selection. Rheumatoid arthritis, ankylosing spondylitis, chronic plaque psoriasis and Crohn’s disease, antibody developed by guided selection phage display	104,105
IGF-1 receptor	Blocking of ligand-binding site of receptor and receptor down-regulation by endocytosis. Potential application in cancer	106
Notch	Prevent proteolysis of juxtamembrane NRR domain	107,108
Met	Dimeric antibodies are agonistic, monomeric ones are antagonistic, and prospected for non-small cell lung cancer	109
MuSK	Agonsitic antibodies demonstrate that MuSK activation is capable of triggering a key event in neuromuscular junction formation	110
CD40	Agonistic antibodies which activate normal human B suppress HIV-1 infection in vitro	111
Hemagglutinin	Antibodies recognize a previously unknown conserved conformational epitope. Isolated from both naïve and immunized libraries.	23,112,113
EphA2 and CD44	Selected from phage antibody library on yeast displayed antigen, followed by selection for internalization on cells	114
CD166	Internalizing antibodies selected directly for internalization on cancer cells (CD166 on prostate, ErbB2 and Transferrin receptor on breast, EGFR on A431). Antigen identified after selection. Potential utility for internalization of chemotherapeutics.	115,116
ErbB2		117
Transferrin receptor		117
EGFR		118
TRAIL-R	Over 500 different scFvs and Fabs isolated by phage display.	119