. Author manuscript; available in PMC: 2011 Mar 15.

Published in final edited form as: Immunogenetics. 2010 Apr 13;62(6):345–356. doi: 10.1007/s00251-010-0439-y

Table 3.

Distribution of IL12B genotypes in patients with uncomplicated and severe malaria.

	Genotype frequency			P(X)

IL12Bpro (rs17860508)	1.1, n (%)	1.2, n (%)	2.2, n (%)
UM	17 (6.8)	185 (74.0)	48 (19.2)	P(2.2)=0.56
SM	14 (13.6)	72 (69.9)	17 (16.5)	P(2.2)=0.51
Total	31 (8.8)	257 (72.8)	65 (18.4)	P(2.2)=0.55
p (UM vs. SM)	p=0.017	p =0.288	p =0.224

IL12B 3’ UTR (rs3212227)	TT, n (%)	TG, n (%)	GG, n (%)

UM	61 (27.1)	104 (46.2)	60 (26.7)	P(G)=0.50
SM	20 (23.8)	34 (40.5)	30 (35.7)	P(G)=0.56
Total	81 (26.2)	138 (44.7)	90 (29.1)	P(G)=0.51
p (UM vs. SM)	p=0.259	p =0.128	p =0.021

Data are presented as proportions, n (%).

UM, uncomplicated malaria (n=252); SM, severe malaria (n=103).

P(X), frequency of the wild allele in the population.

IL12Bpro did not amplify in one subject with UM and one subject with SM, while IL12B 3’ UTR did not amplify in 37 subjects with UM and 9 subjects with SM.

Statistical significance for differences in genotypic frequencies between the UM and SM groups was determined by Chi-square analysis.