Table 2.
Characteristics of biomarker selection
| Tumor vascular normalizing effects |
Tumor antivascular effects |
Systemic effects |
|---|---|---|
| Permeability | Microvessel density | Blood pressure |
| Microvessel density | Vascular volume | Bone-marrow-derived cells (circulating or infiltrating the tumors: effector T Iymphocyes, myeloid cells, progenitor cells) |
| Diameter | NA | NA |
| Interstitial fluid pressure | NA | NA |
| Edema | NA | NA |
| Basement membrane thickness | NA | NA |
| Pericyte coverage | NA | NA |
| Penetration of macromolecules | NA | NA |
| Perfusion | NA | NA |
| Oxygenation | NA | NA |
Abbreviation: NA, not applicable.