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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2010 Nov 13;4(1):87–93. doi: 10.1161/CIRCEP.110.959726

Figure 4.

Figure 4

Allelic expression imbalance analysis of Cx40 transcripts A and B. Significant allelic mRNA imbalance occurred outside of a 95% confidence interval created by the gDNA allelic ratios (dotted lines). Each bar represents a different subject. (a) All of the promoter B SNP heterozygotes displayed consistent allelic expression imbalance of Cx40 transcript B favoring the ‘A’ allele. One sample homozygous for the promoter B SNP but heterozygous at an indicator SNP was included as a negative control (-). (b) Most (30) of the promoter A SNP heterozygotes demonstrated weak allelic expression imbalance of Cx40 transcript A favoring the −44A allele. Two samples were not significantly associated with allelic expression imbalance and another two samples exhibited small but significant mRNA expression imbalance in the opposite direction. (c) Representative sequence tracings at the indicator SNP rs1043806 in gDNA and Cx40 transcript B cDNA from a sample heterozygous for the promoter B SNP.