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. Author manuscript; available in PMC: 2012 Feb 25.
Published in final edited form as: Chem Biol. 2011 Feb 25;18(2):210–221. doi: 10.1016/j.chembiol.2010.12.010

Figure 2. The structure activity relationship of flavonoid-based inhibitors of DnaK-DnaJ.

Figure 2

(A) Approximately 80 flavonoids were chosen based on their structural similarity to EGC (Figure S2) and screened against the DnaK-DnaJ ATPase activity. The activities of select examples are shown in relation to a DMSO solvent control. The ATPase assays were performed in triplicate and the error bars represent standard error of the mean. (DnaK, 0.6 μM; DnaJ, 1 μM) (B) A summary of the structure-activity relationships, highlighting the key structural features of the flavonoid scaffold important for activity against DnaK-DnaJ. (C) Summary of the functional group decoration and activity of select flavonoids. These examples were selected to highlight key SAR observations.