Table 1.
Polymorphism |
Frequency, n (%) |
Odds ratioa |
|||||||
---|---|---|---|---|---|---|---|---|---|
Gene SNP no. |
SNP ID | Location | MAF | Genotype | IBS (n = 199) |
Control (n = 79) |
OR | 95%CI | p-valueb |
TPH1 | rs4537731 | Promoter | 0.38 | AA | 76 (38%) | 29 (37%) | 1 | 0.84 | |
1 | region | AG | 96 (48%) | 41 (52%) | 0.86 | 0.49, 1.5 | |||
GG | 27 (14%) | 9 (11%) | 1.03 | 0.43, 2.5 | |||||
| |||||||||
2 | rs684302 | Intron 2 | 0.44 | CC | 63 (32%) | 27 (34%) | 1 | 0.84 | |
CT | 97 (48%) | 37 (47%) | 1.18 | 0.65, 2.1 | |||||
TT | 39 (20%) | 15 (19%) | 1.21 | 0.57, 2.6 | |||||
| |||||||||
3 | rs211105 | Intron 3 | 0.21 | TT | 124 (62%) | 48 (60%) | 1 | 0.82 | |
GT | 66 (33%) | 28 (35%) | 0.86 | 0.49, 1.5 | |||||
GG | 9 ( 5%) | 3 ( 4%) | 1.20 | 0.31, 4.7 | |||||
| |||||||||
4 | rs1800532 | Intron 7 | 0.42 | CC | 72 (36%) | 28 (35%) | 1 | 0.97 | |
AC | 89 (45%) | 36 (46%) | 0.96 | 0.53, 1.7 | |||||
AA | 38 (19%) | 15 (19%) | 1.04 | 0.49, 2.2 | |||||
| |||||||||
TPH2 | rs4570625 | Promoter | 0.21 | GG | 131 (66%) | 46 (58%) | 1 | 0.05 | |
6 | region | GT | 62 (31%) | 25 (32%) | 0.92 | 0.51, 1.6 | |||
TT | 6 ( 3%) | 8 (10%) | 0.25 | 0.08, 0.8 |
SNP, single nucleotide polymorphism; MAF, minor allele frequency; IBS, irritable bowel syndrome; OR, odds ratio; CI, confidence interval; TPH, tryptophan hydroxylase
Logistic regression adjusted for age
Overall p-value