Table 1.

Characteristics of TPH polymorphisms and their association with IBS in women

		Polymorphism		Frequency, n (%)			Odds ratioa
Gene SNP no.	SNP ID	Location	MAF	Genotype	IBS (n = 199)	Control (n = 79)	OR	95%CI	p-valueb
TPH1	rs4537731	Promoter	0.38	AA	76 (38%)	29 (37%)	1		0.84
1		region		AG	96 (48%)	41 (52%)	0.86	0.49, 1.5
				GG	27 (14%)	9 (11%)	1.03	0.43, 2.5
2	rs684302	Intron 2	0.44	CC	63 (32%)	27 (34%)	1		0.84
				CT	97 (48%)	37 (47%)	1.18	0.65, 2.1
				TT	39 (20%)	15 (19%)	1.21	0.57, 2.6
3	rs211105	Intron 3	0.21	TT	124 (62%)	48 (60%)	1		0.82
				GT	66 (33%)	28 (35%)	0.86	0.49, 1.5
				GG	9 ( 5%)	3 ( 4%)	1.20	0.31, 4.7
4	rs1800532	Intron 7	0.42	CC	72 (36%)	28 (35%)	1		0.97
				AC	89 (45%)	36 (46%)	0.96	0.53, 1.7
				AA	38 (19%)	15 (19%)	1.04	0.49, 2.2
TPH2	rs4570625	Promoter	0.21	GG	131 (66%)	46 (58%)	1		0.05
6		region		GT	62 (31%)	25 (32%)	0.92	0.51, 1.6
				TT	6 ( 3%)	8 (10%)	0.25	0.08, 0.8

SNP, single nucleotide polymorphism; MAF, minor allele frequency; IBS, irritable bowel syndrome; OR, odds ratio; CI, confidence interval; TPH, tryptophan hydroxylase

^aLogistic regression adjusted for age

^bOverall p-value