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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Clin Cancer Res. 2010 Dec 1;16(23):5712–5721. doi: 10.1158/1078-0432.CCR-10-2055

Figure 1.

Figure 1

Conjugation of 10 nm AuNP to cetuximab (C225) via a covalent linker (A) and 20 nm AuNP conjugated to PAM4 single chain IgG via thiol-gold interaction (B) was seen with appropriate shifts in the peak plasmonic absorbance after NaCl challenge. (C) Panc-1 expresses EGFR, the target of C225, while Capan-1 expresses the target of PAM4, MUC-1. Unconjugated and conjugated AuNPs in deionized water (DI) heat in the RF field in a concentration dependent manner (D, * p < 0.0001 between low and high concentrations).