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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Clin Cancer Res. 2010 Dec 1;16(23):5712–5721. doi: 10.1158/1078-0432.CCR-10-2055

Figure 6.

Figure 6

Panc-1 and Capan-1 tumors demonstrated significant increases in necrosis (*) after treatment with antibody conjugated AuNPs and RF field exposure whereas liver tissue remained normal (A). Panc-1 tumors after 6 weeks of combined C225-AuNP treatment and RF exposure (B, top row) are significantly smaller than tumors in mice that just received C225-AuNPs treatment (p = 0.0097, B, bottom row). There was one complete response and one near complete response in the dual treatment group. Cleaved caspase-3 was increased in tumors from mice that had undergone antibody targeted gold nanoparticle treatment and RF field exposure (C, Panc-1 xenograft with DAPI in blue and cleaved caspase-3 labeled in green) compared to tumors from control mice (D, represented by the Panc-1 xenografts from untreated controls). RF exposure after antibody AuNP treatment resulted in significant decreased tumor volumes (E &F)