Figure 2.

Effects of DS on phenylephrine-induced aortic contraction. (a) Representative tracings showing that cumulative addition of DS (10, 30, 100, and 300 μg/mL; arrows) relaxed mouse aorta in a concentration-dependent manner in vessel segments preconstricted with phenylephrine (PE, 1 μmol/L). (b) Average of data from four preparations showing that incubation with 100 μmol/L L-NAME abolished the DS-mediated relaxation. *P < .05 versus control, two-way ANOVA for repeated measures. Error bars indicate standard errors and are shown unidirectionally for clarity.