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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Clin Cancer Res. 2010 Nov 23;17(3):427–436. doi: 10.1158/1078-0432.CCR-09-3069

Figure 4.

Figure 4

Exogenously expressed HtrA1 inhibits lung metastases of endometrial cancer cells. (A) Western blot analysis of HtrA1 expression in Ark 2 clonal lines stably transfected with wild type HtrA1 (WT), protease mutant HtrA1 (SA 18) or empty vector (V1). (B) Representative figure showing micrometastasis of Ark 2 cells in the lung in V1 and SA 18 clonal lines but not in WT clone (Top Panel). (C). Metastasis to lung was attenuated in Ark 2 cells expressing wild type HtrA1 compared to control Ark 2 cells transfected with empty vector. P-values were calculated by Pearson χ2 analysis.