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Downregulation of endogenous HtrA1 in Hec1B promotes lung metastasis of endometrial cancer cells. (A) Western blot analysis of HtrA1 expression in Hec1B clonal lines stably transfected with non-targeting shRNA (NT) or with two different shRNAs targeting HtrA1 (shRNA 1 and shRNA 2). (B) Hematoxylin and Eosin staining of lung tissue from mice injected via tail vein with stable pool of Hec1B cells expressing non-targeted shRNA (NT) or HtrA1-targeted shRNA (shRNA1).
