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. Author manuscript; available in PMC: 2011 Nov 15.
Published in final edited form as: Cancer Res. 2010 Nov 2;70(22):9463–9472. doi: 10.1158/0008-5472.CAN-10-2388

Figure 7. A LIN28/let-7 loop controls mammary gland progenitor cell differentiation.

Figure 7

A. Protocol of mammary gland epithelial cell isolation and lentiviral infection. B. Enforced expression of LIN28 significantly increased the ALDH1br cell population in mammary gland epithelial cells. C. Three types of colonies were identified by Giemsa staining. D. Enforced LIN28 expression led to a significant increase in the number of colonies. E. Enforced expression of let-7 led to a significant decrease in the luminal and mixture types of colonies.