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. Author manuscript; available in PMC: 2011 Mar 15.
Published in final edited form as: Neuron. 2008 Jun 12;58(5):708–719. doi: 10.1016/j.neuron.2008.04.014

Figure 6. Insulin receptor regulates synapse numbers.

Figure 6

(A) Electron micrographs show ultrastructural morphology of synaptic terminals that contact GFP-, wtIR- and dnIR-expressing dendrites. Postsynaptic areas, presynaptic area and the clustered synaptic vesicle were highlighted in light blue, green and pink, respectively. (B) dnIR-expressing dendrites receive significantly fewer synapse contacts compared to GFP- and wtIR-transfected dendrites. (C) Synapses that contact GFP-, wtIR-and dnIR-expressing dendrites show comparable ultrastructural synaptic maturity, determined by the area occupied by clustered synaptic vesicles relative to the area of the presynaptic terminal. (D) GFP-, wtIR- and dnIR-expressing neurons have comparable ranges of postsynaptic profile sizes, represented by the short diameter of labeled postsynaptic area.