Schematic diagram of pathways involving cellular injury and inflammatory-mediated regulation of fibrinolysis through the individual and combined actions of several cytokines and chemokines. Because fibrinolysis is an essential component of provisional matrix establishment and resolution, and angiogenesis and a key part of cellular/tissue repair involving the activation of transforming growth factor (TGF-β), any alteration in this process can often lead to defective fibrinogenic activity and tumorigenesis, including leiomyomas. IFN, interferon; IL, interleukin; MMP, metalloproteinase; PAI, plasminogen activator inhibitor; TIMP, tissue inhibitor of metalloproteinase; TNF, tumor necrosis factor.