FIGURE 7.

Effects of LC_E-BoTIM_A and BoNT_A (WT) on capsaicin-evoked nociceptive behavior in rats. The vehicle or the test toxins indicated were administered by intraplantar injection into the right hind paw 4 days (A–E) or 18 days (F) before measuring nociceptive behavior (A–D and F) and hot plate latency (54.5 ± 1 °C, cut-off time 40 s) (E) at 0–10 or 50 min, respectively, following capsaicin injection into the right hind paw (see “Experimental Procedures”). The data are the means ± S.E. (n = 7–8). *, p < 0.05; **, p < 0.01 versus vehicle-pretreated group using one-way analysis of variance and post-hoc Student-Newman-Keul's test.