Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Nov 24;286(8):6641–6649. doi: 10.1074/jbc.M110.168872

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 9. — A model for the post-transcriptional effect of MeHg for antioxidant selenoenzymes. A, GPx1 cDNA. The UGA codon encoded for Sec resides 105 nucleotides upstream of the sole exon-exon junction. When a UGA codon is recognized as a nonsense codon under selenium deficiency, GPx1 mRNA should be a natural substrate for NMD. B, TrxR1 cDNA. The Sec codon UGA-498 resides in the last exon on TrxR1 mRNA, so TrxR1 mRNA cannot be a substrate for NMD even when a UGA codon is recognized as a nonsense codon under selenium deficiency.